Which side effect is a potential risk with regular use of inhaled corticosteroids?

Inhaled corticosteroids are commonly prescribed for managing asthma and provide significant benefits in controlling inflammation and preventing exacerbations. However, one noteworthy side effect associated with their regular use is oral candidiasis, also known as thrush. This condition arises because inhaled corticosteroids can disrupt the natural balance of flora in the oropharyngeal region, promoting the overgrowth of yeast, particularly Candida.

When inhaled corticosteroids are used, there's a tendency for the medication to deposit in the mouth and throat. If proper mouth rinsing after inhalation isn't practiced, the residual medication may provide an environment conducive to fungal growth, leading to oral thrush. This side effect is particularly concerning because it can occur without any systemic corticosteroid side effects and is often preventable through proper inhaler technique and oral hygiene.

Other potential side effects mentioned, such as weight gain, skin rash, and vomiting, are more commonly associated with systemic corticosteroids and are not typical with the use of inhaled formulations. Inhaled corticosteroids primarily affect localized areas, reducing the likelihood of systemic side effects that might be seen with other forms of steroid administration.