What medication has been shown effective as adjunctive therapy in a severe asthma exacerbation?

Intravenous magnesium sulfate has been shown to be effective as adjunctive therapy in severe asthma exacerbations, particularly when traditional treatments such as bronchodilators and corticosteroids may not be sufficient. Magnesium sulfate works as a bronchodilator, helping to relax the muscles of the airways and improve airway obstruction, which is critical during an asthma exacerbation. It can also reduce inflammation in the airways, further assisting in the management of an acute asthma attack.

In cases of severe exacerbations, especially in patients who are in respiratory distress or are not responding adequately to standard treatments, magnesium sulfate can provide an additional therapeutic benefit. Its use in the emergency setting reflects its effectiveness in improving lung function and reducing the risk of hospitalization.

Contextually, while high-dose inhaled corticosteroids can be essential in managing chronic asthma and preventing exacerbations, they are not typically used for immediate relief during acute episodes. Albuterol, a short-acting beta-agonist, is vital for quick bronchodilation during an attack but is not classified as adjunctive therapy since it is a primary treatment. Leukotriene receptor antagonists, while used in long-term asthma management, are not effective during acute exacerbations and do not offer the rapid response required in such